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HAT1 rabbit pAb

CAT: 0855-ES7804-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES7804-02Size:100 µL
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Background
The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009]
Description
The protein encoded by this gene is a type B histone acetyltransferase (HAT) that is involved in the rapid acetylation of newly synthesized cytoplasmic histones, which are in turn imported into the nucleus for de novo deposition onto nascent DNA chains. Histone acetylation, particularly of histone H4, plays an important role in replication-dependent chromatin assembly. Specifically, this HAT can acetylate soluble but not nucleosomal histone H4 at lysines 5 and 12, and to a lesser degree, histone H2A at lysine 5. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Jun 2009],
Product Name Alternative
HAT1; KAT1; Histone acetyltransferase type B catalytic subunit; Histone acetyltransferase 1
UniProt
O14929
Swiss Prot
O14929
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human HAT. AA range:331-380
Target
HAT1
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
49kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
49kD
Fragment
IgG
Subcellular Location
[Isoform A]: Nucleus matrix . Mitochondrion .; [Isoform B]: Cytoplasm . Nucleus . Nucleus matrix . Nucleus, nucleoplasm . Localization is predominantly nuclear in normal cells. Treatment with hydrogen peroxide or ionizing radiation enhances nuclear localization through redistribution of existing protein. .
Other Product Names
HAT1; KAT1; Histone acetyltransferase type B catalytic subunit; Histone acetyltransferase 1
Gene ID (Human)
8520

UniProtKB · O14929

Histone acetyltransferase type B catalytic subunit

HAT1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O14929
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
HAT1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.3.1.48
Processing
—
Secondary accessions
Q49A44, Q53QF0, Q53SU4, Q6P594, Q8WWB9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Molecular function

AcyltransferaseTransferase

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmMitochondrionNucleus

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