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COL25A1 rabbit pAb

CAT: 0855-ES7762-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES7762-01Size:50 µL
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Background
This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410) . A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013) . Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Description
This gene encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011],
UniProt
Q9BXS0
Swiss Prot
Q9BXS0
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human Collagen XXV alpha1. AA range:101-150
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
64kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
64kD
Fragment
IgG
Subcellular Location
Membrane ; Single-pass type II membrane protein . After proteolytic cleavage, CLAC is secreted.
Other Product Names
COL25A1; Collagen alpha-1 (XXV) chain; Alzheimer disease amyloid-associated protein; AMY; CLAC-P
Gene ID (Human)
84570

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