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ATRIP (phospho Ser224) rabbit pAb

CAT: 0855-ES7733-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES7733-01Size:50 µL
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Background
This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012]
Description
This gene encodes an essential component of the DNA damage checkpoint. The encoded protein binds to single-stranded DNA coated with replication protein A. The protein also interacts with the ataxia telangiectasia and Rad3 related protein kinase, resulting in its accumulation at intranuclear foci induced by DNA damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2012],
UniProt
Q8WXE1
Swiss Prot
Q8WXE1
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human ATRIP around the phosphorylation site of Ser224. AA range:190-239
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
86kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
86kD
Fragment
IgG
Subcellular Location
Nucleus . Redistributes to discrete nuclear foci upon DNA damage.
Other Product Names
ATRIP; AGS1; ATR-interacting protein; ATM and Rad3-related-interacting protein
Gene ID (Human)
84126

UniProtKB · Q8WXE1

ATR-interacting protein

ATRIP_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8WXE1
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ATRIP
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
A8K6A3, A8K714, B2RCE7, B4DU92, B5MEB7, Q69YK9, Q8NHQ2, Q8WUG7, Q96CL3, Q9HA30
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Domain

Coiled coil

Biological process

DNA damageDNA repair

Cellular component

Nucleus

PTM

Phosphoprotein

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