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Tensin-1 rabbit pAb

CAT: 0855-ES7409-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES7409-01Size:50 µL
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Background
The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
Description
The protein encoded by this gene localizes to focal adhesions, regions of the plasma membrane where the cell attaches to the extracellular matrix. This protein crosslinks actin filaments and contains a Src homology 2 (SH2) domain, which is often found in molecules involved in signal transduction. This protein is a substrate of calpain II. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015],
Product Name Alternative
TNS1; TNS; Tensin-1
UniProt
Q9HBL0
Swiss Prot
Q9HBL0
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human Tensin-1. AA range:1273-1322
Target
Tensin-1
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
200kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
200kD
Fragment
IgG
Subcellular Location
Cell surface . Cell junction, focal adhesion . Cytoplasm, cytoskeleton . Localized at cell periphery preferentially to fibrillar adhesions than focal adhesions. Translocates from the cell edge to cell center in an ITGB1BP1-dependent manner.
Other Product Names
TNS1; TNS; Tensin-1
Gene ID (Human)
7145

UniProtKB · Q9HBL0

Tensin-1

TENS1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9HBL0
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
TNS1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.3.-
Processing
—
Secondary accessions
A0A804HI61, Q4ZG71, Q6IPI5
Protein keywords

Molecular function

Actin-bindingHydrolaseProtein phosphatase

Coding sequence diversity

Alternative splicing

Cellular component

Cell junctionCytoplasmCytoskeleton

Technical term

Direct protein sequencingProteomics identificationReference proteome

PTM

GlycoproteinPhosphoprotein

Ligand

Metal-bindingZinc

Domain

SH2 domainZinc-finger

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Alternative Products

CatalogName
NBP1-84130-25ulRabbit Polyclonal Tensin 1 Antibody
GB114263Anti-Tensin 1 Rabbit pAb
E28PT4603Tensin-1 Rabbit Polyclonal Antibody
GTR18052722-01Tensin-1 rabbit pAb Antibody
TA382689Tensin 1 (TNS1) Rabbit Polyclonal Antibody
E53P06004Tensin-1 Tyr1326 Rabbit Polyclonal Antibody
YLD7673-01Rabbit anti-Tensin 1 (pY1326) Antibody
NBP2-78783PERabbit Polyclonal Tensin 1 Antibody [PE]
NBP2-78783FRabbit Polyclonal Tensin 1 Antibody [FITC]
NBP2-78783APCRabbit Polyclonal Tensin 1 Antibody [Allophycocyanin]

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