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Bub1 rabbit pAb

CAT: 0855-ES7357-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES7357-02Size:100 µL
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Background
This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Description
This gene encodes a serine/threonine-protein kinase that play a central role in mitosis. The encoded protein functions in part by phosphorylating members of the mitotic checkpoint complex and activating the spindle checkpoint. This protein also plays a role in inhibiting the activation of the anaphase promoting complex/cyclosome. This protein may also function in the DNA damage response. Mutations in this gene have been associated with aneuploidy and several forms of cancer. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013],
UniProt
O43683
Swiss Prot
O43683
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human BUB1. AA range:251-300
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Nucleus. Chromosome, centromere, kinetochore. Nuclear in interphase cells. Accumulates gradually during G1 and S phase of the cell cycle, peaks at G2/M, and drops dramatically after mitosis. Localizes to the outer kinetochore. Kinetochore localization is required for normal mitotic timing and checkpoint response to spindle damage and occurs very early in prophase. AURKB, KNL1 and INCENP are required for kinetochore localization (By similarity) . .
Other Product Names
BUB1; BUB1L; Mitotic checkpoint serine/threonine-protein kinase BUB1; hBUB1; BUB1A
Gene ID (Human)
699

UniProtKB · O43683

Mitotic checkpoint serine/threonine-protein kinase BUB1

BUB1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O43683
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
BUB1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
hBUB1
EC number
2.7.11.1
Processing
—
Secondary accessions
E9PC26, F5GXI5, O43430, O43643, O60626, Q53QE4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisCell cycleCell divisionChromosome partitionHost-virus interactionMitosis

Ligand

ATP-bindingNucleotide-binding

Cellular component

CentromereChromosomeKinetochoreNucleus

Disease

Intellectual disabilityPrimary microcephaly

Molecular function

KinaseSerine/threonine-protein kinaseTransferase

PTM

PhosphoproteinUbl conjugation

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