ETL rabbit pAb

CAT: 0855-ES7151-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0855-ES7151-01Size:50 µL

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Background

Developmental stage:Up-regulated in the adult heart., domain:The transmembrane domain is not required for cleavage, but it is required for dimer formation., function:Could be involved in cardiac development., PTM:Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit., similarity:Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily., similarity:Contains 1 GPS domain., similarity:Contains 2 EGF-like domains., subunit:Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit) . Forms stable dimer at the cells surface., tissue specificity:Mainly expressed in smooth muscle.

Description

Developmental stage: Up-regulated in the adult heart. Domain: The transmembrane domain is not required for cleavage, but it is required for dimer formation. function: Could be involved in cardiac development. PTM: Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit. similarity: Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. similarity: Contains 1 GPS domain. similarity: Contains 2 EGF-like domains. subunit: Forms a heterodimer, consisting of a large extracellular region (alpha subunit) non-covalently linked to a seven-transmembrane moiety (beta subunit). Forms stable dimer at the cells surface. tissue specificity: Mainly expressed in smooth muscle.

UniProt

Q9HBW9

Swiss Prot

Q9HBW9

Reactivity

Human; Rat; Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human ELTD1. AA range:251-300

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.

Molecular Weight

77kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

77kD

Fragment

IgG

Subcellular Location

Cell membrane ; Multi-pass membrane protein .

Other Product Names

ELTD1; ETL; EGF; latrophilin and seven transmembrane domain-containing protein 1; EGF-TM7-latrophilin-related protein; ETL protein

Gene ID (Human)

64123

UniProtKB · Q9HBW9

Adhesion G protein-coupled receptor L4

AGRL4_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9HBW9
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: ADGRL4
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: Precursor
Secondary accessions: B1AR71, Q5KU34

Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

Calcium

Cellular component

Cell membraneMembrane

PTM

Disulfide bondGlycoprotein

Domain

EGF-like domainRepeatSignalTransmembraneTransmembrane helix

Molecular function

G protein-coupled receptorReceptorTransducer

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