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RNase Z2 rabbit pAb

CAT: 0855-ES7054-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES7054-01Size:50 µL
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Background
The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Description
The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009],
UniProt
Q9BQ52
Swiss Prot
Q9BQ52
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human ELAC2. AA range:161-210
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Mitochondrion . Mitochondrion matrix, mitochondrion nucleoid . Nucleus . Mainly mitochondrial.
Other Product Names
ELAC2; HPC2; Zinc phosphodiesterase ELAC protein 2; ElaC homolog protein 2; Heredity prostate cancer protein 2; Ribonuclease Z 2; RNase Z 2; tRNA 3 endonuclease 2; tRNase Z 2
Gene ID (Human)
60528

UniProtKB · Q9BQ52

Zinc phosphodiesterase ELAC protein 2

RNZ2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q9BQ52
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ELAC2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.26.11
Processing
Precursor
Secondary accessions
B4DPL9, Q6IA94, Q9HAS8, Q9HAS9, Q9NVT1
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Disease

Disease variantPrimary mitochondrial diseaseProto-oncogene

Molecular function

EndonucleaseHydrolaseNuclease

Ligand

Metal-bindingZinc

Cellular component

MitochondrionMitochondrion nucleoidNucleus

PTM

Phosphoprotein

Domain

Transit peptide

Biological process

tRNA processing

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