ELOVL5 rabbit pAb

CAT: 0855-ES7052-01Size: 50 µLDry Ice: NoHazardous: No

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CAT#:0855-ES7052-01Size:50 µL

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Background

This gene belongs to the ELO family. It is highly expressed in the adrenal gland and testis, and encodes a multi-pass membrane protein that is localized in the endoplasmic reticulum. This protein is involved in the elongation of long-chain polyunsaturated fatty acids. Mutations in this gene have been associated with spinocerebellar ataxia-38 (SCA38) . Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014]

Description

This gene belongs to the ELO family. It is highly expressed in the adrenal gland and testis, and encodes a multi-pass membrane protein that is localized in the endoplasmic reticulum. This protein is involved in the elongation of long-chain polyunsaturated fatty acids. Mutations in this gene have been associated with spinocerebellar ataxia-38 (SCA38). Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2014],

UniProt

Q9NYP7

Swiss Prot

Q9NYP7

Reactivity

Human; Rat; Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human ELOVL5. AA range:250-299

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

Molecular Weight

28kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

28kD

Fragment

IgG

Subcellular Location

Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cell projection, dendrite . In Purkinje cells, the protein localizes to the soma and proximal portion of the dendritic tree. .

Other Product Names

ELOVL5; ELOVL2; Elongation of very long chain fatty acids protein 5; 3-keto acyl-CoA synthase ELOVL5; ELOVL fatty acid elongase 5; ELOVL FA elongase 5; Fatty acid elongase 1; hELO1

Gene ID (Human)

60481

UniProtKB · Q9NYP7

Very long chain fatty acid elongase 5

ELOV5_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: Q9NYP7
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: ELOVL5
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: 2.3.1.199
Processing: —
Secondary accessions: B4DZJ2, F6SH78, Q59EL3, Q5TGH5, Q6NXE7, Q7L2S5, Q8NCG4, Q9UI22

Protein keywords

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Cellular component

Cell projectionEndoplasmic reticulumMembrane

Disease

Disease variantNeurodegenerationSpinocerebellar ataxia

Biological process

Fatty acid biosynthesisFatty acid metabolismLipid biosynthesisLipid metabolism

Technical term

Proteomics identificationReference proteome

Molecular function

Transferase

Domain

TransmembraneTransmembrane helix

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