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RGS7 rabbit pAb

CAT: 0855-ES7042-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES7042-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G (o) -alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations., PTM:Palmitoylated., PTM:Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity., similarity:Contains 1 DEP domain., similarity:Contains 1 G protein gamma domain., similarity:Contains 1 RGS domain., subunit:Heterodimer with GNG5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity) . Interacts with 14-3-3 protein Tau and SNAP25BP.
Description
Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G (o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations. PTM: Palmitoylated. PTM: Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity. similarity: Contains 1 DEP domain. similarity: Contains 1 G protein gamma domain. similarity: Contains 1 RGS domain. subunit: Heterodimer with GNG5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity). Interacts with 14-3-3 protein Tau and SNAP25BP.
Product Name Alternative
RGS7; Regulator of G-protein signaling 7; RGS7
UniProt
P49802
Swiss Prot
P49802
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human RGS7. AA range:155-204
Target
RGS7
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Buffer
-20°C/1 year
Molecular Weight
65kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
65kD
Fragment
IgG
Subcellular Location
Cytoplasm, cytosol . Cytoplasm . Cell membrane . Membrane ; Peripheral membrane protein ; Cytoplasmic side . Interaction with PKD1 promotes location at the cell membrane (PubMed:10339594) . Interaction with RGS7BP promotes location at the cell membrane (PubMed:15897264) . .
Other Product Names
RGS7; Regulator of G-protein signaling 7; RGS7
Gene ID (Human)
6000

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