PTPα rabbit pAb

CAT: 0855-ES6939-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES6939-01Size:50 µL
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Background
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008]
Description
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported. [provided by RefSeq, Jul 2008],
UniProt
P18433
Swiss Prot
P18433
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from PTPα . at AA range: 730-810
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Molecular Weight
90kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
90kD
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type I membrane protein . Cell junction, focal adhesion . Localizes to focal adhesion sites following integrin engagement. .
Other Product Names
PTPRA; PTPA; PTPRL2; Receptor-type tyrosine-protein phosphatase alpha; Protein-tyrosine phosphatase alpha; R-PTP-alpha
Gene ID (Human)
5786

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