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PKC ε rabbit pAb

CAT: 0855-ES6781-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES6781-01Size:50 µL
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Background
Protein kinase C epsilon (PRKCE) Homo sapiens Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS) -mediated signaling in activated macro
Description
Protein kinase C epsilon (PRKCE) Homo sapiens Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells. The protein encoded by this gene is one of the PKC family members. This kinase has been shown to be involved in many different cellular functions, such as neuron channel activation, apoptosis, cardioprotection from ischemia, heat shock response, as well as insulin exocytosis. Knockout studies in mice suggest that this kinase is important for lipopolysaccharide (LPS)-mediated signaling in activated macro
Product Name Alternative
PRKCE; PKCE; Protein kinase C epsilon type; nPKC-epsilon
UniProt
Q02156
Swiss Prot
Q02156
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human PKC epsilon. AA range:688-737
Target
PKC ε
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000
Buffer
-20°C/1 year
Molecular Weight
83kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
83kD
Fragment
IgG
Subcellular Location
Cytoplasm . Cytoplasm, cytoskeleton . Cell membrane . Cytoplasm, perinuclear region . Nucleus . Translocated to plasma membrane in epithelial cells stimulated by HGF (PubMed:17603037) . Associated with the Golgi at the perinuclear site in pre-passage fibroblasts (By similarity) . In passaging cells, translocated to the cell periphery (By similarity) . Translocated to the nucleus in PMA-treated cells (By similarity) . .
Other Product Names
PRKCE; PKCE; Protein kinase C epsilon type; nPKC-epsilon
Gene ID (Human)
5581

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