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Atg16 rabbit pAb

CAT: 0855-ES6700-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES6700-01Size:50 µL
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Background
The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10) . Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jun 2010]
Description
The protein encoded by this gene is part of a large protein complex that is necessary for autophagy, the major process by which intracellular components are targeted to lysosomes for degradation. Defects in this gene are a cause of susceptibility to inflammatory bowel disease type 10 (IBD10). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010],
Product Name Alternative
ATG16L1; APG16L; Autophagy-related protein 16-1; APG16-like 1
UniProt
Q676U5
Swiss Prot
Q676U5
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from Atg16 . at AA range: 60-140
Target
Atg16
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
70kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
70kD
Fragment
IgG
Subcellular Location
Cytoplasm . Preautophagosomal structure membrane ; Peripheral membrane protein . Endosome membrane ; Peripheral membrane protein . Lysosome membrane ; Peripheral membrane protein . Recruited to omegasomes membranes by WIPI2 (By similarity) . Omegasomes are endoplasmic reticulum connected strutures at the origin of preautophagosomal structures (By similarity) . Localized to preautophagosomal structure (PAS) where it is involved in the membrane targeting of ATG5 (By similarity) . Localizes also to discrete punctae along the ciliary axoneme (By similarity) . Upon activation of non-canonical autophagy, recruited to single-membrane endolysosomal compartments (PubMed:29317426) . .
Other Product Names
ATG16L1; APG16L; Autophagy-related protein 16-1; APG16-like 1
Gene ID (Human)
55054

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