PP1α (phospho Thr320) rabbit pAb

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Background

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1) . PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Description

The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008],

UniProt

P62136

Swiss Prot

P62136

Reactivity

Human; Mouse; Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human PP1-alpha around the phosphorylation site of Thr320. AA range:281-330

Clonality

Polyclonal

Source

Rabbit

Applications

IHC; IF; ELISA

Concentration

1 mg/ml

Dilution

Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.

Storage Conditions

-20°C/1 year

Fragment

IgG

Subcellular Location

Cytoplasm . Nucleus . Nucleus, nucleoplasm . Nucleus, nucleolus . Primarily nuclear and largely excluded from the nucleolus. Highly mobile in cells and can be relocalized through interaction with targeting subunits. NOM1 plays a role in targeting this protein to the nucleolus. In the presence of PPP1R8 relocalizes from the nucleus to nuclear speckles. Shuttles toward the cytosol during infection with VEEV (PubMed:29769351) . .

Other Product Names

PPP1CA; PPP1A; Serine/threonine-protein phosphatase PP1-alpha catalytic subunit; PP-1A

Gene ID (Human)

5499

UniProtKB · P62136

Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

PP1A_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P62136
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: PPP1CA
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: PP-1A
EC number: 3.1.3.16
Processing: —
Secondary accessions: A6NNR3, B2R908, P08129, P20653, P22802, Q07161

Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Biological process

Carbohydrate metabolismCell cycleCell divisionGlycogen metabolismHost-virus interaction

Cellular component

CytoplasmNucleusSynapse

Molecular function

HydrolaseProtein phosphatase

Ligand

ManganeseMetal-binding

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Alternative Products

Catalog	Name
12807-01	PP1α (Phospho-Thr320) Antibody
E19-2990-2	Phospho-PP1α (Thr320) Antibody
A0726-01	PP1α (phospho Thr320) Antibody
8A0726-AAT	PP1-α (Phospho-Thr320) Antibody
APRab05294-01	PP1α (phospho Thr320) Rabbit Polyclonal Antibody
MBS9502627-01	PP1-alpha (Phospho-Thr320) Antibody
UB-GEN-14306	PP1α (phospho Thr320) Polyclonal Antibody
OAAF07498-100UG	PP1-alpha Antibody (Phospho-Thr320)
abx217749-01	Phospho-PP1 alpha (Thr320) Antibody
JOT-AP13239-01	PP1 alpha(Phospho Thr320) Polyclonal Antibody