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PinX1 rabbit pAb

CAT: 0855-ES6688-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES6688-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
Domain:The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibit its activity., function:Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor., similarity:Belongs to the PINX1 family., similarity:Contains 1 G-patch domain., subcellular location:In nucleoli and at telomere speckles., subunit:Binds to MCRS1, TERT and TERF1., tissue specificity:Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.
Description
Domain: The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibit its activity. function: Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. similarity: Belongs to the PINX1 family. similarity: Contains 1 G-patch domain. subcellular location: In nucleoli and at telomere speckles. subunit: Binds to MCRS1, TERT and TERF1. tissue specificity: Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.
UniProt
Q96BK5
Swiss Prot
Q96BK5
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human PINX1. AA range:121-170
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Nucleus . Nucleus, nucleolus. Chromosome, telomere. Chromosome, centromere, kinetochore. Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.
Other Product Names
PINX1; LPTL; LPTS; PIN2/TERF1-interacting telomerase inhibitor 1; Liver-related putative tumor suppressor; Pin2-interacting protein X1; Protein 67-11-3; TRF1-interacting protein 1
Gene ID (Human)
54984

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