Products for Research Use Only
RegisterLogin

ATP7A rabbit pAb

CAT: 0855-ES6626-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0855-ES6626-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
ATPase copper transporting alpha (ATP7A) Homo sapiens This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in this gene are associated with Menkes disease, X-linked distal spinal muscular atrophy, and occipital horn syndrome. Alternatively-spliced transcript variants have been observed. [provided by RefSeq, Aug 2013]
Description
ATPase copper transporting alpha (ATP7A) Homo sapiens This gene encodes a transmembrane protein that functions in copper transport across membranes. This protein is localized to the trans Golgi network, where it is predicted to supply copper to copper-dependent enzymes in the secretory pathway. It relocalizes to the plasma membrane under conditions of elevated extracellular copper, and functions in the efflux of copper from cells. Mutations in this gene are associated with Menkes disease, X-linked distal spinal muscular atrophy, and occipital horn syndrome. Alternatively-spliced transcript variants have been observed. [provided by RefSeq, Aug 2013],
UniProt
Q04656
Swiss Prot
Q04656
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human ATP7A. AA range:591-640
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Golgi apparatus, trans-Golgi network membrane ; Multi-pass membrane protein . Cell membrane ; Multi-pass membrane protein . Melanosome membrane ; Multi-pass membrane protein . Early endosome membrane ; Multi-pass membrane protein . Cell projection, axon . Cell projection, dendrite . Cell junction, synapse, postsynaptic density . Cycles constitutively between the TGN and the plasma membrane (PubMed:9147644) . Predominantly found in the TGN and relocalized to the plasma membrane in response to elevated copper levels. Targeting into melanosomes is regulated by BLOC-1 complex (By similarity) . In response to glutamate, translocates to neuron processes with a minor fraction at extrasynaptic sites (By similarity) . .; [Isoform 3]: Cytoplasm, cytosol .; [Isoform 5]: Endoplasmic reticulum .
Other Product Names
ATP7A; MC1; MNK; Copper-transporting ATPase 1; Copper pump 1; Menkes disease-associated protein
Gene ID (Human)
538

Related Products

CatalogName
ES6635-01ATP7B rabbit pAb
ES1726-01ATP5A rabbit pAb
ES10038-01ATP4A rabbit pAb
ES4666-01RAB3IP rabbit pAb
ES20751-01Gab1 Rabbit rabbit pAb
ES20703-01JAK2 Rabbit rabbit pAb
ES20758-01ERK1 Rabbit rabbit pAb
ES20830-01ATG14L Rabbit rabbit pAb
ES20829-01ATG4a Rabbit rabbit pAb
ES20658-01NM23A Rabbit rabbit pAb

Alternative Products

CatalogName
A28232-01ATP7A Rabbit mAb
GTR18597025-01ATP7A Rabbit pAb
GTR17865792ATP7A Rabbit Polyclonal Antibody
NBP3-10578-100ulRabbit Polyclonal ATP7A Antibody
YLD0713-01Rabbit anti-ATP7A Antibody
307286-01ATP7A
YP-W24779-01Mouse ATP7a (ATP7a) ELISA Kit

Popular Products