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PR (phospho Ser294) rabbit pAb

CAT: 0855-ES6579-01Size: 50 µLDry Ice: NoHazardous: No
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Background
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015]
Description
This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both protein coding and non-protein coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015],
UniProt
P06401
Swiss Prot
P06401
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human Progesterone Receptor around the phosphorylation site of Ser294. AA range:261-310
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC
Concentration
1 mg/ml
Dilution
WB 1:500-2000; IHC-p 1:50-300
Molecular Weight
98kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
98kD
Fragment
IgG
Subcellular Location
Nucleus. Cytoplasm. Nucleoplasmic shuttling is both hormone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G (1) and G (2) /M phases.; [Isoform A]: Nucleus. Cytoplasm. Mainly nuclear.; [Isoform 4]: Mitochondrion outer membrane .
Other Product Names
PGR; NR3C3; Progesterone receptor; PR; Nuclear receptor subfamily 3 group C member 3
Gene ID (Human)
5241

UniProtKB · P06401

Progesterone receptor

PRGR_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P06401
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
PGR
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
PR
EC number
—
Processing
—
Secondary accessions
A7LQ08, A7X8B0, B4E3T0, Q8TDS3, Q9UPF7
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative promoter usageAlternative splicing

Cellular component

CytoplasmMembraneMitochondrionMitochondrion outer membraneNucleus

Molecular function

DNA-bindingReceptor

PTM

Isopeptide bondLipoproteinPalmitatePhosphoproteinUbl conjugation

Ligand

Lipid-bindingMetal-bindingSteroid-bindingZinc

Biological process

TranscriptionTranscription regulation

Domain

Zinc-finger

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