GPR143 rabbit pAb

CAT: 0855-ES6437-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES6437-01Size:50 µL
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Background
This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y. [provided by RefSeq, Dec 2009]
Description
This gene encodes a protein that binds to heterotrimeric G proteins and is targeted to melanosomes in pigment cells. This protein is thought to be involved in intracellular signal transduction mechanisms. Mutations in this gene cause ocular albinism type 1, also referred to as Nettleship-Falls type ocular albinism, a severe visual disorder. A related pseudogene has been identified on chromosome Y. [provided by RefSeq, Dec 2009],
Product Name Alternative
GPR143; OA1; G-protein coupled receptor 143; Ocular albinism type 1 protein
UniProt
P51810
Swiss Prot
P51810
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human GPR143. AA range:151-200
Target
GPR143
Clonality
Polyclonal
Source
Rabbit
Applications
IF; ELISA
Concentration
1 mg/ml
Dilution
Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Melanosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein . Apical cell membrane ; Multi-pass membrane protein . Distributed throughout the endo-melanosomal system but most of endogenous protein is localized in unpigmented stage II melanosomes. Its expression on the apical cell membrane is sensitive to tyrosine (PubMed:18828673) . .
Other Product Names
GPR143; OA1; G-protein coupled receptor 143; Ocular albinism type 1 protein
Gene ID (Human)
4935

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