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Cleaved-Notch 2 (A1734) rabbit pAb

CAT: 0855-ES6407-01Size: 50 µLDry Ice: NoHazardous: No
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Background
Notch 2 (NOTCH2) Homo sapiens This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cle
Description
Notch 2 (NOTCH2) Homo sapiens This gene encodes a member of the Notch family. Members of this Type 1 transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple, different domain types. Notch family members play a role in a variety of developmental processes by controlling cell fate decisions. The Notch signaling network is an evolutionarily conserved intercellular signaling pathway which regulates interactions between physically adjacent cells. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signaling pathway that plays a key role in development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remain to be determined. This protein is cle
Product Name Alternative
NOTCH2; Neurogenic locus notch homolog protein 2; Notch 2; hN2
UniProt
Q04721
Swiss Prot
Q04721
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human NOTCH2. AA range:1715-1764
Target
Notch 2
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
110(cleaved)kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
110 (cleaved) kD
Fragment
IgG
Subcellular Location
[Notch 2 extracellular truncation]: Cell membrane ; Single-pass type I membrane protein .; [Notch 2 intracellular domain]: Nucleus . Cytoplasm . Following proteolytical processing NICD is translocated to the nucleus. Retained at the cytoplasm by TCIM (PubMed:25985737) . .
Other Product Names
NOTCH2; Neurogenic locus notch homolog protein 2; Notch 2; hN2
Gene ID (Human)
4853

UniProtKB · Q04721

Neurogenic locus notch homolog protein 2

NOTC2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q04721
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NOTCH2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
Notch 2, hN2
EC number
—
Processing
Precursor
Secondary accessions
Q5T3X7, Q99734, Q9H240
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Molecular function

ActivatorDevelopmental proteinReceptor

Domain

ANK repeatEGF-like domainRepeatSignalTransmembraneTransmembrane helix

Cellular component

Cell membraneCytoplasmMembraneNucleus

Biological process

DifferentiationNotch signaling pathwayTranscriptionTranscription regulation

Disease

Disease variantOsteoporosis

PTM

Disulfide bondGlycoproteinPhosphoproteinUbl conjugation

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