Cleaved-Notch 1 (V1754) rabbit pAb

Cleaved-Notch 1 (V1754) rabbit pAb

• Description: Notch 1 (NOTCH1) Homo sapiens This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymph
• Synonyms: NOTCH1; TAN1; Neurogenic locus notch homolog protein 1; Notch 1; hN1; Translocation-associated notch protein TAN-1
• Gene ID: 4851
• UniProt: P46531
• Cellular Locus: Cell membrane ; Single-pass type I membrane protein.; [Notch 1 intracellular domain]: Nucleus. Following proteolytical processing NICD is translocated to the nucleus. Nuclear location may require MEGF10..
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: The antiserum was produced against synthesized peptide derived from human Notch 1. AA range:1735-1784
• Clonality: Polyclonal
• Validated Applications: WB, IF, IHC, ELISA
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: WB 1:500-2000, IHC-p 1:50-300, IF 1:50-300
• Molecular Weight: 110kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.