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ENOS (phospho Thr494) rabbit pAb

CAT: 0855-ES6399-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES6399-01Size:50 µL
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Background
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Description
Nitric oxide is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. Nitric oxide is synthesized from L-arginine by nitric oxide synthases. Variations in this gene are associated with susceptibility to coronary spasm. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009],
Product Name Alternative
NOS3; Nitric oxide synthase; endothelial; Constitutive NOS; cNOS; EC-NOS; Endothelial NOS; eNOS; NOS type III; NOSIII
UniProt
P29474
Swiss Prot
P29474
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human eNOS around the phosphorylation site of Thr494. AA range:462-511
Target
NOS3/eNOS
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/5000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
130-140kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
130-140kD
Fragment
IgG
Subcellular Location
Cell membrane. Membrane, caveola. Cytoplasm, cytoskeleton. Golgi apparatus. Specifically associates with actin cytoskeleton in the G2 phase of the cell cycle; which is favored by interaction with NOSIP and results in a reduced enzymatic activity.
Other Product Names
NOS3; Nitric oxide synthase; endothelial; Constitutive NOS; cNOS; EC-NOS; Endothelial NOS; eNOS; NOS type III; NOSIII
Gene ID (Human)
4846

UniProtKB · P29474

Nitric oxide synthase 3

NOS3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P29474
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
NOS3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
1.14.13.39
Processing
—
Secondary accessions
A0S0A7, A0S0A8, A8KA63, B2RCQ1, E9PFR2, Q13662, Q14251, Q14434, Q548C1, Q6GSL5, Q9UDC6
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumFADFlavoproteinFMNHemeIronMetal-bindingNADPZinc

Molecular function

Calmodulin-bindingOxidoreductase

Cellular component

Cell membraneCytoplasmCytoskeletonGolgi apparatusMembrane

PTM

LipoproteinMyristatePalmitatePhosphoprotein

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