AF-4 rabbit pAb

CAT: 0855-ES6253-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES6253-01Size:50 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in mu
Description
This gene encodes a member of the AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome family of proteins, which have been implicated in childhood lymphoblastic leukemia, Fragile X E site mental retardation, and ataxia. It is the prevalent mixed-lineage leukemia fusion gene associated with spontaneous acute lymphoblastic leukemia. Members of this family have three conserved domains: an N-terminal homology domain, an AF4/ lymphoid nuclear protein related to AF4/Fragile X E mental retardation syndrome domain, and a C-terminal homology domain. The protein functions as a regulator of RNA polymerase II-mediated transcription through elongation and chromatin remodeling functions. Through RNA interference screens, this gene has been shown to promote the expression of CD133, a plasma membrane glycoprotein required for leukemia cell survival. Alternative splicing results in mu
UniProt
P51825
Swiss Prot
P51825
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human AF4. AA range:1-50
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
130kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
130kD
Fragment
IgG
Subcellular Location
Nucleus .
Other Product Names
AFF1; AF4; FEL; MLLT2; PBM1; AF4/FMR2 family member 1; ALL1-fused gene from chromosome 4 protein; Protein AF-4; Protein FEL; Proto-oncogene AF4
Gene ID (Human)
4299

Related Products

CatalogName
ES1609-01AF-10 rabbit pAb
ES1745-01Bag-4 rabbit pAb
ES6420-01NT-4 rabbit pAb
ES4518-01Mad 4 rabbit pAb
ES1956-01Cerebellin 4 rabbit pAb
ES6007-01KIR3.4 rabbit pAb
ES2691-01Kv3.4 rabbit pAb
ES3398-01Rsk-4 rabbit pAb
ES5123-014.1R rabbit pAb
ES6171-01MAP-4 rabbit pAb

Alternative Products

CatalogName
E47R5958AF 4 Rabbit pAb
E28PT0140AF-4 Rabbit Polyclonal Antibody
SL5958R-01Rabbit Anti-AF 4 antibody
PAV4743Rabbit Anti-AF-4/AFF1 Polyclonal Antibody
MBS679213-01Rabbit IgG-LE/AF
E28PT0139AF-10 Rabbit Polyclonal Antibody
OASB02653-500UGRabbit IgG Antibody : LE/AF
E28PN8303AF-6 Rabbit Polyclonal Antibody
NBP1-90220Rabbit Polyclonal Afadin/AF-6 Antibody
NBP1-22996HRabbit Polyclonal Afadin/AF-6 Antibody [HRP]

Popular Products