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Rho H rabbit pAb

CAT: 0855-ES6118-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES6118-01Size:50 µL
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Background
The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP) -metabolizing enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal translocations in non-Hodgkin's lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome 3, leading to the production of fusion transcripts. Alternative splicing in the 5' untranslated region results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2013]
Description
The protein encoded by this gene is a member of the Ras superfamily of guanosine triphosphate (GTP)-metabolizing enzymes. The encoded protein is expressed in hematopoietic cells, where it functions as a negative regulator of cell growth and survival. This gene may be hypermutated or misexpressed in leukemias and lymphomas. Chromosomal translocations in non-Hodgkin's lymphoma occur between this locus and B-cell CLL/lymphoma 6 (BCL6) on chromosome 3, leading to the production of fusion transcripts. Alternative splicing in the 5' untranslated region results in multiple transcript variants that encode the same protein. [provided by RefSeq, May 2013],
Product Name Alternative
RHOH; ARHH; TTF; Rho-related GTP-binding protein RhoH; GTP-binding protein TTF; Translocation three four protein
UniProt
Q15669
Swiss Prot
Q15669
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human RhoH. AA range:141-190
Target
Rho H
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
21kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
21kD
Fragment
IgG
Subcellular Location
Cytoplasm . Cell membrane ; Lipid-anchor ; Cytoplasmic side . Colocalizes together with ZAP70 in the immunological synapse. .
Other Product Names
RHOH; ARHH; TTF; Rho-related GTP-binding protein RhoH; GTP-binding protein TTF; Translocation three four protein
Gene ID (Human)
399

UniProtKB · Q15669

Rho-related GTP-binding protein RhoH

RHOH_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q15669
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
RHOH
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.6.5.2
Processing
Precursor
Secondary accessions
—
Protein keywords

Cellular component

Cell membraneCytoplasmMembrane

Coding sequence diversity

Chromosomal rearrangement

Disease

Disease variant

Ligand

GTP-bindingMagnesiumMetal-bindingNucleotide-binding

Molecular function

Hydrolase

PTM

LipoproteinMethylationPhosphoproteinPrenylation

Technical term

Proteomics identificationReference proteome

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