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Rho G rabbit pAb

CAT: 0855-ES6076-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES6076-01Size:50 µL
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011]
Description
This gene encodes a member of the Rho family of small GTPases, which cycle between inactive GDP-bound and active GTP-bound states and function as molecular switches in signal transduction cascades. Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape, attachment, and motility. The encoded protein facilitates translocation of a functional guanine nucleotide exchange factor (GEF) complex from the cytoplasm to the plasma membrane where ras-related C3 botulinum toxin substrate 1 is activated to promote lamellipodium formation and cell migration. Two related pseudogene have been identified on chromosomes 20 and X. [provided by RefSeq, Aug 2011],
UniProt
P84095
Swiss Prot
P84095
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human RHOG. AA range:97-146
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
Molecular Weight
23kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
23kD
Fragment
IgG
Subcellular Location
Cell membrane ; Lipid-anchor ; Cytoplasmic side .
Other Product Names
RHOG; ARHG; Rho-related GTP-binding protein RhoG
Gene ID (Human)
391

UniProtKB · P84095

Rho-related GTP-binding protein RhoG

RHOG_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P84095
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
RHOG
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.6.5.2
Processing
Precursor
Secondary accessions
P35238, Q8NI04
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

ADP-ribosylationGlycoproteinLipoproteinMethylationPhosphoproteinPrenylation

Cellular component

Cell membraneMembrane

Disease

Disease variant

Ligand

GTP-bindingMagnesiumMetal-bindingNucleotide-binding

Molecular function

Hydrolase

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