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IP3R-I rabbit pAb

CAT: 0855-ES5965-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES5965-01Size:50 µL
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Background
This gene encodes an intracellular receptor for inositol 1,4,5-trisphosphate. Upon stimulation by inositol 1,4,5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009]
Description
This gene encodes an intracellular receptor for inositol 1, 4, 5-trisphosphate. Upon stimulation by inositol 1, 4, 5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009],
Product Name Alternative
ITPR1; INSP3R1; Inositol 1; 4,5-trisphosphate receptor type 1; IP3 receptor isoform 1; IP3R 1; InsP3R1; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor
UniProt
Q14643
Swiss Prot
Q14643
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human InsP3R1. AA range:1566-1615
Target
IP3 Receptor
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, secretory vesicle membrane ; Multi-pass membrane protein . Cytoplasm, perinuclear region . Endoplasmic reticulum and secretory granules (By similarity) . .
Other Product Names
ITPR1; INSP3R1; Inositol 1; 4,5-trisphosphate receptor type 1; IP3 receptor isoform 1; IP3R 1; InsP3R1; Type 1 inositol 1,4,5-trisphosphate receptor; Type 1 InsP3 receptor
Gene ID (Human)
3708

UniProtKB · Q14643

Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

ITPR1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q14643
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ITPR1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
E7EPX7, E9PDE9, Q14660, Q99897
Protein keywords

Coding sequence diversity

Alternative splicing

Biological process

ApoptosisCalcium transportIon transportTransport

Ligand

ATP-bindingCalciumMetal-bindingNucleotide-bindingZinc

Molecular function

Calcium channelIon channelLigand-gated ion channelReceptor

Cellular component

CytoplasmCytoplasmic vesicleEndoplasmic reticulumMembrane

Disease

Disease variantIntellectual disabilityNeurodegenerationSpinocerebellar ataxia

PTM

Disulfide bondGlycoproteinIsopeptide bondLipoproteinPalmitatePhosphoproteinUbl conjugation

Technical term

Proteomics identificationReference proteome

Domain

RepeatTransmembraneTransmembrane helix

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