IP3R-I (phospho Ser1598) rabbit pAb

• Description:

  This gene encodes an intracellular receptor for inositol 1, 4, 5-trisphosphate. Upon stimulation by inositol 1, 4, 5-trisphosphate, this receptor mediates calcium release from the endoplasmic reticulum. Mutations in this gene cause spinocerebellar ataxia type 15, a disease associated with an heterogeneous group of cerebellar disorders. Multiple transcript variants have been identified for this gene. [provided by RefSeq, Nov 2009],

• Synonyms:

  ITPR1; INSP3R1; Inositol 1; 4, 5-trisphosphate receptor type 1; IP3 receptor isoform 1; IP3R 1; InsP3R1; Type 1 inositol 1, 4, 5-trisphosphate receptor; Type 1 InsP3 receptor

• Gene ID:

  3708

• UniProt:

  Q14643

• Cellular Locus:

  Endoplasmic reticulum membrane ; Multi-pass membrane protein. Cytoplasmic vesicle, secretory vesicle membrane ; Multi-pass membrane protein. Cytoplasm, perinuclear region. Endoplasmic reticulum and secretory granules (By similarity)..

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human Inositol 1,4,5-trisphosphate R1 around the phosphorylation site of Ser1598/1588. AA range:1566-1615

• Clonality:

  Polyclonal

• Validated Applications:

  IHC, IF, ELISA

• Stability:

  1 year

• Concentration:

  1 mg/mL

• Dilution:

  Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.