Lck BP-1 rabbit pAb

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CAT#:0855-ES5724-01Size:50 µL

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Background

Developmental stage:Expressed in early stage of myeloid and erythroid differentiation., function:Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression., PTM:Phosphorylated by LYN; rapidly after cross-linking of surface IgM on B-cells., similarity:Contains 1 SH3 domain., similarity:Contains 4 cortactin repeats., subunit:Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN, but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1, through binding to its C-terminal region. Interacts with HS1BP3., tissue specificity:Expressed only in tissues and cells of hematopoietic origin.

Description

Developmental stage: Expressed in early stage of myeloid and erythroid differentiation. function: Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression. PTM: Phosphorylated by LYN; rapidly after cross-linking of surface IgM on B-cells. similarity: Contains 1 SH3 domain. similarity: Contains 4 cortactin repeats. subunit: Associates with the SH2 and SH3 domains of LCK. Binding to he LCK SH3 domain occurs constitutively, while binding to the LCK SH2 domain occurs only upon TCR stimulation. A similar binding pattern was observed with LYN, but not with FYN in which the FYN SH2 region associates upon TCR stimulation but the FYN SH3 region does not associate regardless of TCR stimulation. Directly associates with HAX1, through binding to its C-terminal region. Interacts with HS1BP3. tissue specificity: Expressed only in tissues and cells of hematopoietic origin.

UniProt

P14317

Swiss Prot

P14317

Reactivity

Human; Rat; Mouse

Immunogen

Synthesized peptide derived from Lck BP-1 . at AA range: 340-420

Clonality

Polyclonal

Source

Rabbit

Applications

WB; IHC

Concentration

1 mg/ml

Dilution

WB 1:500-2000; IHC-p 1:50-300

Molecular Weight

54kD

Storage Conditions

-20°C/1 year

Observed Molecular Weight

54kD

Fragment

IgG

Subcellular Location

Membrane ; Peripheral membrane protein . Cytoplasm . Mitochondrion .

Other Product Names

HCLS1; HS1; Hematopoietic lineage cell-specific protein; Hematopoietic cell-specific LYN substrate 1; LckBP1; p75

Gene ID (Human)

3059

UniProtKB · P14317

Hematopoietic lineage cell-specific protein

HCLS1_HUMAN · Homo sapiens

View on UniProt ↗

Primary accession: P14317
Review status: UniProtKB reviewed (Swiss-Prot)
Gene: HCLS1
Protein existence: 1: Evidence at protein level
Organism: Homo sapiens (Human)
Taxonomy ID: 9606
Alternative names: —
EC number: —
Processing: —
Secondary accessions: B4DQ69, Q53Y93, Q6IBK9, Q9UDK0

Protein keywords

PTM

AcetylationPhosphoprotein

Coding sequence diversity

Alternative splicing

Cellular component

CytoplasmMembraneMitochondrion

Technical term

Direct protein sequencingProteomics identificationReference proteome

Domain

RepeatSH3 domain

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