14-3-3 σ rabbit pAb

14-3-3 σ rabbit pAb

• Description: Function: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. function: p53-regulated inhibitor of G2/M progression. similarity: Belongs to the 14-3-3 family. subcellular location: May be secreted by a non-classical secretory pathway. subunit: Homodimer. Interacts with KRT17 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. tissue specificity: Present mainly in tissues enriched in stratified squamous keratinising epithelium.
• Synonyms: SFN; HME1; 14-3-3 protein sigma; Epithelial cell marker protein 1; Stratifin
• Gene ID: 2810
• UniProt: P31947
• Cellular Locus: Cytoplasm. Nucleus. Secreted. May be secreted by a non-classical secretory pathway.
• Host: Rabbit
• Species Reactivity: Human, Mouse
• Immunogen: The antiserum was produced against synthesized peptide derived from human SFN. AA range:41-90
• Clonality: Polyclonal
• Validated Applications: WB, IHC, IF, ELISA
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: IHC-p: 100-300.Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
• Molecular Weight: 30kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.