INPP5J rabbit pAb

• Background:

  Catalytic activity:1D-myo-inositol 1,3,4,5-tetrakisphosphate + H (2) O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate., catalytic activity:D-myo-inositol 1,4,5-trisphosphate + H (2) O = myo-inositol 1,4-bisphosphate + phosphate., domain:The 5 Arg-Ser-Xaa-Ser-Xaa-Xaa (RSXSXX) motifs may constitute binding sites for the 14-3-3 protein., function:Inositol 5-phosphatase, which converts inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate. Also converts phosphatidylinositol 4,5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1,3,4,5-tetrakisphosphate to inositol 1,3,4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles., PTM:Phosphorylated at Ser/Thr residues., similarity:Belongs to the inositol-1,4,5-trisphosphate 5-phosphatase type II family., subcellular location:Predominantly localized to membrane ruffles.

• Description:

  Catalytic activity: 1D-myo-inositol 1, 3, 4, 5-tetrakisphosphate + H (2)O = 1D-myo-inositol 1, 3, 4-trisphosphate + phosphate. Catalytic activity: D-myo-inositol 1, 4, 5-trisphosphate + H (2)O = myo-inositol 1, 4-bisphosphate + phosphate. Domain: The 5 Arg-Ser-Xaa-Ser-Xaa-Xaa (RSXSXX) motifs may constitute binding sites for the 14-3-3 protein. function: Inositol 5-phosphatase, which converts inositol 1, 4, 5-trisphosphate to inositol 1, 4-bisphosphate. Also converts phosphatidylinositol 4, 5-bisphosphate to phosphatidylinositol 4-phosphate and inositol 1, 3, 4, 5-tetrakisphosphate to inositol 1, 3, 4-trisphosphate in vitro. May be involved in modulation of the function of inositol and phosphatidylinositol polyphosphate-binding proteins that are present at membranes ruffles. PTM: Phosphorylated at Ser/Thr residues. similarity: Belongs to the inositol-1, 4, 5-trisphosphate 5-phosphatase type II family. subcellular location: Predominantly localized to membrane ruffles.

• UniProt:

  Q15735

• Swiss Prot:

  Q15735

• Reactivity:

  Human; Rat

• Immunogen:

  Synthesized peptide derived from INPP5J . at AA range: 850-930

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  IHC; IF; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

• Storage Conditions:

  -20°C/1 year

• Fragment:

  IgG

• Subcellular Location:

  Cytoplasm . Predominantly localized to membrane ruffles. .

• Other Product Names:

  INPP5J; PIB5PA; PIPP; Phosphatidylinositol 4; 5-bisphosphate 5-phosphatase A; Inositol polyphosphate 5-phosphatase J

• Gene ID (Human):

  27124