GABAB R1 rabbit pAb

• Background:

  This gene encodes a receptor for gamma-aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mammalian central nervous system. This receptor functions as a heterodimer with GABA (B) receptor 2. Defects in this gene may underlie brain disorders such as schizophrenia and epilepsy. Alternative splicing generates multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jan 2016]

• Description:

  This gene encodes a receptor for gamma-aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the mammalian central nervous system. This receptor functions as a heterodimer with GABA (B) receptor 2. Defects in this gene may underlie brain disorders such as schizophrenia and epilepsy. Alternative splicing generates multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jan 2016],

• UniProt:

  Q9UBS5

• Swiss Prot:

  Q9UBS5

• Reactivity:

  Human; Mouse; Rat; Guinea pig

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human GABBR1. AA range:891-940

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; IF; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.

• Molecular Weight:

  108kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  108kD

• Fragment:

  IgG

• Subcellular Location:

  Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell projection, dendrite . Colocalizes with ATF4 in hippocampal neuron dendritic membranes (By similarity) . Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane (PubMed:15617512) . .; [Isoform 1E]: Secreted .

• Other Product Names:

  GABBR1; GPRC3A; Gamma-aminobutyric acid type B receptor subunit 1; GABA-B receptor 1; GABA-B-R1; GABA-BR1; GABABR1; Gb1

• Gene ID (Human):

  2550