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GABAB R2 rabbit pAb

CAT: 0855-ES8063-01Size: 50 µLDry Ice: NoHazardous: No
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Background
The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence.[provided by RefSeq, Jan 2010]
Description
The multi-pass membrane protein encoded by this gene belongs to the G-protein coupled receptor 3 family and GABA-B receptor subfamily. The GABA-B receptors inhibit neuronal activity through G protein-coupled second-messenger systems, which regulate the release of neurotransmitters, and the activity of ion channels and adenylyl cyclase. This receptor subunit forms an active heterodimeric complex with GABA-B receptor subunit 1, neither of which is effective on its own. Allelic variants of this gene have been associated with nicotine dependence. [provided by RefSeq, Jan 2010],
UniProt
O75899
Swiss Prot
O75899
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from GABAB R2 . at AA range: 830-910
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
105kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
105kD
Fragment
IgG
Subcellular Location
Cell membrane ; Multi-pass membrane protein . Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Coexpression of GABBR1 and GABBR2 is required for GABBR1 maturation and transport to the plasma membrane. In contrast, GABBR2 does not depend on GABBR1 for transport to the cell membrane. .
Other Product Names
GABBR2; GPR51; GPRC3B; Gamma-aminobutyric acid type B receptor subunit 2; GABA-B receptor 2; GABA-B-R2; GABA-BR2; GABABR2; Gb2; G-protein coupled receptor 51; HG20
Gene ID (Human)
9568

UniProtKB · O75899

Gamma-aminobutyric acid type B receptor subunit 2

GABR2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
O75899
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
GABBR2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
GABA-B receptor 2, GABA-B-R2, GABA-BR2, GABABR2, Gb2
EC number
—
Processing
Precursor
Secondary accessions
O75974, O75975, Q5VXZ2, Q8WX04, Q9P1R2, Q9UNR1, Q9UNS9
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Cellular component

Cell membraneMembranePostsynaptic cell membraneSynapse

Domain

Coiled coilSignalTransmembraneTransmembrane helix

Disease

Disease variantEpilepsyIntellectual disability

PTM

Disulfide bondGlycoproteinPhosphoprotein

Molecular function

G protein-coupled receptorReceptorTransducer

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