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PC-PLD3 rabbit pAb

CAT: 0855-ES5376-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES5376-01Size:50 µL
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Background
This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2014]
Description
This gene encodes a member of the phospholipase D (PLD) family of enzymes that catalyze the hydrolysis of membrane phospholipids. The encoded protein is a single-pass type II membrane protein and contains two PLD phosphodiesterase domains. This protein influences processing of amyloid-beta precursor protein. Mutations in this gene are associated with Alzheimer disease risk. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Apr 2014],
UniProt
Q8IV08
Swiss Prot
Q8IV08
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human PLD3. AA range:326-375
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Endoplasmic reticulum membrane ; Single-pass type II membrane protein . Lysosome lumen . Early endosome membrane ; Single-pass type II membrane protein . Late endosome membrane ; Single-pass type II membrane protein . Golgi apparatus membrane ; Single-pass type II membrane protein . Endosome membrane ; Single-pass type II membrane protein . Localizes to ER-associated vesicles in differentiating myotubes (PubMed:22428023) . The soluble form in lysosome arises by proteolytic processing of the membrane-bound form (PubMed:29386126) . Colocalizes with APP in endosomes (PubMed:29368044) . .
Other Product Names
PLD3; Phospholipase D3; PLD 3; Choline phosphatase 3; HindIII K4L homolog; Hu-K4; Phosphatidylcholine-hydrolyzing phospholipase D3
Gene ID (Human)
23646

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