BACE rabbit pAb

CAT: 0855-ES5373-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES5373-01Size:50 µL
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Background
Beta-secretase 1 (BACE1) Homo sapiens This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015]
Description
Beta-secretase 1 (BACE1) Homo sapiens This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid Beta peptide from amyloid precursor protein. Amyloid Beta peptides are the main constituent of amyloid Beta plaques, which accumulate in the brains of human Alzheimer's disease patients. [provided by RefSeq, Nov 2015],
Product Name Alternative
BACE1; BACE; KIAA1149; Beta-secretase 1; Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2
UniProt
P56817
Swiss Prot
P56817
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human BACE. AA range:452-501
Target
BACE
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/5000. Not yet tested in other applications.
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type I membrane protein . Golgi apparatus, trans-Golgi network . Endoplasmic reticulum . Endosome . Cell surface . Cytoplasmic vesicle membrane ; Single-pass type I membrane protein . Membrane raft . Lysosome . Late endosome . Early endosome . Recycling endosome . Cell projection, axon . Cell projection, dendrite . Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface (PubMed:17425515, PubMed:11466313) . Colocalization with APP in early endosomes is due to addition of bisecting N-acetylglucosamine wich blocks targeting to late endosomes and lysosomes (By similarity) . Retrogradly transported from end
Other Product Names
BACE1; BACE; KIAA1149; Beta-secretase 1; Aspartyl protease 2; ASP2; Asp 2; Beta-site amyloid precursor protein cleaving enzyme 1; Beta-site APP cleaving enzyme 1; Memapsin-2; Membrane-associated aspartic protease 2
Gene ID (Human)
23621

Related Products

CatalogName
ES20057-01BACE (Acetyl Lys316) rabbit pAb
ES20141-01BACE (Phospho Ser498) rabbit pAb
ES11348-01BACE2 rabbit pAb
ES4666-01RAB3IP rabbit pAb
ES20751-01Gab1 Rabbit rabbit pAb
ES20703-01JAK2 Rabbit rabbit pAb
ES20758-01ERK1 Rabbit rabbit pAb
ES20599-01VEGF Rabbit rabbit pAb
ES20825-01ATG7 Rabbit rabbit pAb
ES20596-01WIPI2 Rabbit rabbit pAb

Alternative Products

CatalogName
E2252549BACE Rabbit pAb
E60M0595BACE Rabbit mAb
APRab07418-01BACE Rabbit Polyclonal Antibody
E28G1535BACE Rabbit Monoclonal Antibody
HY-P86180-01BACE Antibody (YA5872, Rabbit)
HY-P82169-01BACE Antibody (YA1914, Rabbit)
NBP2-68624-25ulRabbit Polyclonal BACE-2 Antibody
ERTB0642Rabbit BACE 2 ELISA Kit
E28PK0101BACE (Acetyl Lys316) rabbit pAb
RA22284-01BACE (Phospho Ser498) rabbit pAb

Popular Products