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Fibrinogen β rabbit pAb

CAT: 0855-ES5239-01Size: 50 µLDry Ice: NoHazardous: No
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CAT#:0855-ES5239-01Size:50 µL
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Background
The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Description
The protein encoded by this gene is the beta component of fibrinogen, a blood-borne glycoprotein comprised of three pairs of nonidentical polypeptide chains. Following vascular injury, fibrinogen is cleaved by thrombin to form fibrin which is the most abundant component of blood clots. In addition, various cleavage products of fibrinogen and fibrin regulate cell adhesion and spreading, display vasoconstrictor and chemotactic activities, and are mitogens for several cell types. Mutations in this gene lead to several disorders, including afibrinogenemia, dysfibrinogenemia, hypodysfibrinogenemia and thrombotic tendency. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014],
UniProt
P02675
Swiss Prot
P02675
Reactivity
Human; Rat; Mouse
Immunogen
Synthesized peptide derived from the Internal region of human Fibrinogen β.
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.
Molecular Weight
55kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
55kD
Fragment
IgG
Subcellular Location
Secreted .
Other Product Names
FGB; Fibrinogen beta chain
Gene ID (Human)
2244

UniProtKB · P02675

Fibrinogen beta chain

FIBB_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P02675
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
FGB
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
A0JLR9, B2R7G3, Q32Q65, Q3KPF2
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Biological process

Adaptive immunityBlood coagulationHemostasisImmunityInnate immunity

Domain

Coiled coilSignal

Disease

Disease variant

PTM

Disulfide bondGlycoproteinPyrrolidone carboxylic acid

Cellular component

Secreted

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