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4E-BP1 (phospho Thr37) rabbit pAb

CAT: 0855-ES5076-01Size: 50 µLDry Ice: NoHazardous: No
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Background
Eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1) Homo sapiens This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]
Description
Eukaryotic translation initiation factor 4E binding protein 1 (EIF4EBP1) Homo sapiens This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008],
UniProt
Q13541
Swiss Prot
Q13541
Reactivity
Human; Mouse; Rat; Rabbit; Ch; Mk; sheep; X; Fish; Chicken; Guinea pig; Guinea pig; Sheep; Bovine
Immunogen
The antiserum was produced against synthesized peptide derived from human 4E-BP1 around the phosphorylation site of Thr36. AA range:4-53
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
18kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
18kD
Fragment
IgG
Subcellular Location
Nucleoplasm, cytoplasm, cytosol, protein complex
Other Product Names
EIF4EBP1; Eukaryotic translation initiation factor 4E-binding protein 1; 4E-BP1; eIF4E-binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I
Gene ID (Human)
1978

UniProtKB · Q13541

Eukaryotic translation initiation factor 4E-binding protein 1

4EBP1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q13541
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
EIF4EBP1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
4E-BP1, eIF4E-binding protein 1
EC number
—
Processing
—
Secondary accessions
B2R502, D3DSW8, Q6IBN3
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Cellular component

CytoplasmNucleus

Molecular function

Protein synthesis inhibitor

Biological process

Translation regulation

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