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ACE1 rabbit pAb

CAT: 0855-ES4973-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES4973-02Size:100 µL
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Background
This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010]
Description
This gene encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active. [provided by RefSeq, May 2010],
UniProt
P12821
Swiss Prot
P12821
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human ACE1. AA range:891-940
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Molecular Weight
165kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
165kD
Fragment
IgG
Subcellular Location
[Angiotensin-converting enzyme, soluble form]: Secreted.; Cell membrane; Single-pass type I membrane protein. Cytoplasm . Detected in both cell membrane and cytoplasm in neurons. .
Other Product Names
ACE; DCP; DCP1; Angiotensin-converting enzyme; ACE; Dipeptidyl carboxypeptidase I; Kininase II; CD antigen CD143
Gene ID (Human)
1636

UniProtKB · P12821

Angiotensin-converting enzyme

ACE_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P12821
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ACE
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
ACE
EC number
3.4.15.1
Processing
Precursor
Secondary accessions
B0LPF0, B4DXI3, E7EU16, P22966, Q53YX9, Q59GY8, Q7M4L4
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative promoter usageAlternative splicing

Molecular function

Calmodulin-bindingCarboxypeptidaseHydrolaseMetalloproteaseProtease

Cellular component

Cell membraneCytoplasmMembraneSecreted

PTM

Disulfide bondGlycoproteinPhosphoprotein

Ligand

Metal-bindingZinc

Domain

RepeatSignalTransmembraneTransmembrane helix

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