Nesprin-3 rabbit pAb

• Background:

  Function:Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which theters the nucleus to the cytoskeleton by binding PLEC1/Plectin which can associate with the intermediate filament system., similarity:Belongs to the nesprin family., similarity:Contains 1 KASH domain., similarity:Contains 2 spectrin repeats., subcellular location:Located at the rough reticulum endoplasmic (RER) in some cells., subunit:Interacts with actin-binding domain of PLEC1/plectin.

• Description:

  Function: Involved in the maintenance of nuclear organization and structural integrity. Probable anchoring protein which theters the nucleus to the cytoskeleton by binding PLEC1/Plectin which can associate with the intermediate filament system. similarity: Belongs to the nesprin family. similarity: Contains 1 KASH domain. similarity: Contains 2 spectrin repeats. subcellular location: Located at the rough reticulum endoplasmic (RER) in some cells. subunit: Interacts with actin-binding domain of PLEC1/plectin.

• UniProt:

  Q6ZMZ3

• Swiss Prot:

  Q6ZMZ3

• Reactivity:

  Human; Mouse

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human C14orf49. AA range:169-218

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; IF; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  Western Blot: 1/500 - 1/2000. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.

• Molecular Weight:

  115kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  115kD

• Fragment:

  IgG

• Subcellular Location:

  Nucleus outer membrane ; Single-pass type IV membrane protein . Nucleus envelope . Rough endoplasmic reticulum .

• Other Product Names:

  SYNE3; C14orf49; Nesprin-3; Nuclear envelope spectrin repeat protein 3

• Gene ID (Human):

  161176