Products for Research Use Only
RegisterLogin

Sgo2 rabbit pAb

CAT: 0855-ES4904-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0855-ES4904-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Function:During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis (By similarity) . May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., sequence caution:Contaminating sequence. Potential poly-A sequence., similarity:Belongs to the shugoshin family., subcellular location:In Hela cells, localizes at centromeres throughout prophase until metaphase and disappears at anaphase., subunit:Directly interacts with PPP2CA.
Description
Function: During meiosis, protects centromeric cohesion complexes until metaphase II/anaphase II transition, preventing premature release of meiosis-specific REC8 cohesin complexes from anaphase I centromeres. Is thus essential for an accurate gametogenesis (By similarity). May act by targeting PPP2CA to centromeres, thus leading to cohesin dephosphorylation. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. sequence Caution: Contaminating sequence. Potential poly-A sequence. similarity: Belongs to the shugoshin family. subcellular location: In Hela cells, localizes at centromeres throughout prophase until metaphase and disappears at anaphase. subunit: Directly interacts with PPP2CA.
UniProt
Q562F6
Swiss Prot
Q562F6
Reactivity
Human; Rat; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human SGOL2. AA range:681-730
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Nucleus . Chromosome, centromere . Chromosome, centromere, kinetochore . During meiosis I, accumulates at centromeres during diplotene, and colocalizes differentially with the cohesin subunits RAD21 and REC8 at metaphase I centromeres (By similarity) . SGO2 and RAD21 change their relative distributions during telophase I when sister-kinetochore association is lost (By similarity) . During meiosis II, it shows a striking tension-dependent redistribution within centromeres throughout chromosome congression during prometaphase II, as it does during mitosis (By similarity) . In Hela cells, localizes at centromeres throughout prophase until metaphase and disappears at anaphase (PubMed:17485487) . Centromeric localization requires the presence of BUB1 and AUKRB (PubMed:17485487) . .
Other Product Names
SGOL2; Shugoshin-like 2; Shugoshin-2; Sgo2; Tripin
Gene ID (Human)
151246

Related Products

CatalogName
ES3434-01Sgo1 rabbit pAb
ES4909-01Sgo1 (phospho Ser14) rabbit pAb
ES4666-01RAB3IP rabbit pAb
ES20751-01Gab1 Rabbit rabbit pAb
ES20703-01JAK2 Rabbit rabbit pAb
ES20758-01ERK1 Rabbit rabbit pAb
ES20830-01ATG14L Rabbit rabbit pAb
ES20829-01ATG4a Rabbit rabbit pAb
ES20658-01NM23A Rabbit rabbit pAb
ES20826-01ATG5 Rabbit rabbit pAb

Alternative Products

CatalogName
GTR18219514-01Rabbit SGO2 Antibody
GTR18183285SGO2 Rabbit Polyclonal Antibody
TA324690SGOL2 (SGO2) Rabbit Polyclonal Antibody
GTR18746837SGO2 Rabbit Polyclonal Antibody (Fluoro488)
GTR18540535SGO2 Rabbit Polyclonal Antibody (Cy3)
GTR18540533SGO2 Rabbit Polyclonal Antibody (FITC)
GTR18540532SGO2 Rabbit Polyclonal Antibody (HRP)
CST 50616SSGO2 (E9K4N) Rabbit Monoclonal Antibody
GTR18540531SGO2 Rabbit Polyclonal Antibody (APC)
GTR18540530SGO2 Rabbit Polyclonal Antibody (PE)

Popular Products