Csk (phospho Ser364) rabbit pAb

Csk (phospho Ser364) rabbit pAb

• Description: Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. function: Specifically phosphorylates 'Tyr-504' on LCK, which acts as a negative regulatory site. Can also act on the LYN and FYN kinases. PTM: Autophosphorylation of Tyr-304 occurs only at abnormally high CSK concentrations in vitro. similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. CSK subfamily. similarity: Contains 1 protein kinase domain. similarity: Contains 1 SH2 domain. similarity: Contains 1 SH3 domain. subcellular location: Mainly cytoplasmic, also present in lipid rafts. subunit: Interacts with PTPN8 (By similarity). Interacts with phosphorylated SIT1, PAG1, LIME1 and TGFB1I1. tissue specificity: Expressed in lung and macrophages.
• Synonyms: CSK; Tyrosine-protein kinase CSK; C-Src kinase; Protein-tyrosine kinase CYL
• Gene ID: 1445
• UniProt: P41240
• Cellular Locus: Cytoplasm. Cell membrane. Mainly cytoplasmic, also present in lipid rafts..
• Host: Rabbit
• Species Reactivity: Human, Mouse, Rat
• Immunogen: The antiserum was produced against synthesized peptide derived from human Csk around the phosphorylation site of Ser364. AA range:330-379
• Clonality: Polyclonal
• Validated Applications: WB, IHC, IF, ELISA
• Stability: 1 year
• Concentration: 1 mg/mL
• Dilution: Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/10000. Not yet tested in other applications.
• Molecular Weight: 55kD
• Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.