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ACTR-IC rabbit pAb

CAT: 0855-ES4754-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES4754-02Size:100 µL
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Background
ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]) .[supplied by OMIM, Mar 2008]
Description
ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al. 2001 [PubMed 12063393]). [supplied by OMIM, Mar 2008],
Product Name Alternative
ACVR1C; ALK7; Activin receptor type-1C; Activin receptor type IC; ACTR-IC; Activin receptor-like kinase 7; ALK-7
UniProt
Q8NER5
Swiss Prot
Q8NER5
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human ACTR-1C. AA range:201-250
Target
ACTR-IC
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Storage Conditions
-20°C/1 year
Fragment
IgG
Subcellular Location
Membrane ; Single-pass type I membrane protein .
Other Product Names
ACVR1C; ALK7; Activin receptor type-1C; Activin receptor type IC; ACTR-IC; Activin receptor-like kinase 7; ALK-7
Gene ID (Human)
130399

UniProtKB · Q8NER5

Activin receptor type-1C

ACV1C_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q8NER5
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ACVR1C
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
2.7.11.30
Processing
Precursor
Secondary accessions
Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2
Protein keywords

Coding sequence diversity

Alternative splicing

Biological process

Apoptosis

Ligand

ATP-bindingMagnesiumManganeseMetal-bindingNucleotide-binding

Molecular function

KinaseReceptorSerine/threonine-protein kinaseTransferase

Cellular component

Membrane

Technical term

Proteomics identificationReference proteome

Domain

SignalTransmembraneTransmembrane helix

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