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CB1 rabbit pAb

CAT: 0855-ES4723-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES4723-02Size:100 µL
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Background
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009]
Description
This gene encodes one of two cannabinoid receptors. The cannabinoids, principally delta-9-tetrahydrocannabinol and synthetic analogs, are psychoactive ingredients of marijuana. The cannabinoid receptors are members of the guanine-nucleotide-binding protein (G-protein) coupled receptor family, which inhibit adenylate cyclase activity in a dose-dependent, stereoselective and pertussis toxin-sensitive manner. The two receptors have been found to be involved in the cannabinoid-induced CNS effects (including alterations in mood and cognition) experienced by users of marijuana. Multiple transcript variants encoding two different protein isoforms have been described for this gene. [provided by RefSeq, May 2009],
Product Name Alternative
CNR1; CNR; Cannabinoid receptor 1; CB-R; CB1; CANN6
UniProt
P21554
Swiss Prot
P21554
Reactivity
Human; Mouse; Rat; Monkey
Immunogen
The antiserum was produced against synthesized peptide derived from human CNR1. AA range:151-200
Target
CB1
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
53kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
53kD
Fragment
IgG
Subcellular Location
Cell membrane ; Multi-pass membrane protein . Membrane raft . Mitochondrion outer membrane . Cell projection, axon . Cell junction, synapse, presynapse . Unexpectedly, in the mitochondria, the C-terminus is located in the mitochondrial intermembrane space, a compartment topologically considered as extracellular. In canonical seven-transmembrane G-protein coupled receptors, the C-terminus is cytosolic (By similarity) . Found on presynaptic axon terminals in some GABAergic neurons in the somatosensory cortex (By similarity) . .
Other Product Names
CNR1; CNR; Cannabinoid receptor 1; CB-R; CB1; CANN6
Gene ID (Human)
1268

UniProtKB · P21554

Cannabinoid receptor 1

CNR1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P21554
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CNR1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
CB-R, CB1
EC number
—
Processing
—
Secondary accessions
B2R9T4, E1P512, Q13949, Q495Z0, Q4PLI4, Q4VBM6, Q5JVL5, Q5UB37, Q9UNN0
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Cellular component

Cell membraneCell projectionMembraneMitochondrionMitochondrion outer membraneSynapse

Molecular function

G protein-coupled receptorReceptorTransducer

PTM

GlycoproteinLipoproteinPalmitatePhosphoprotein

Disease

NeurodegenerationObesity

Domain

TransmembraneTransmembrane helix

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