cPLA2-ε rabbit pAb
CAT:
855-ES4712-02
Size:
100 μL
Price:
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
cPLA2-ε rabbit pAb
- Description: Catalytic activity: Phosphatidylcholine + H (2)O = 1-acylglycerophosphocholine + a carboxylate. Domain: The N-terminal C2 domain associates with lipid membranes and mediates its regulation by presenting the active site to its substrate in response to elevations of cytosolic Ca (2+). enzyme regulation: Stimulated by cytosolic Ca (2+). function: Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. similarity: Contains 1 C2 domain. similarity: Contains 1 PLA2c domain. subcellular location: Translocates to lysosomal membranes in a calcium-dependent fashion.
- Synonyms: PLA2G4E; Cytosolic phospholipase A2 epsilon; cPLA2-epsilon; Phospholipase A2 group IVE
- Gene ID: 123745
- UniProt: Q3MJ16
- Cellular Locus: Cytoplasm, cytosol. Early endosome membrane ; Peripheral membrane protein ; Cytoplasmic side. Lysosome membrane ; Peripheral membrane protein ; Cytoplasmic side. Cell membrane ; Peripheral membrane protein; Cytoplasmic side. Targeted to clathrin-independent endocytotic vesicles through binding to phosphoinositides, especially phosphatidylinositol 4,5-bisphosphates..
- Host: Rabbit
- Species Reactivity: Human, Rat, Mouse,
- Immunogen: The antiserum was produced against synthesized peptide derived from human PLA2G4E. AA range:401-450
- Clonality: Polyclonal
- Validated Applications: IHC, IF, ELISA
- Stability: 1 year
- Concentration: 1 mg/mL
- Dilution: Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.
- Storage Conditions: PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.