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CHP rabbit pAb

CAT: 0855-ES4626-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES4626-02Size:100 µL
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Background
This gene encodes a phosphoprotein that binds to the Na+/H+ exchanger NHE1. This protein serves as an essential cofactor which supports the physiological activity of NHE family members and may play a role in the mitogenic regulation of NHE1. The protein shares similarity with calcineurin B and calmodulin and it is also known to be an endogenous inhibitor of calcineurin activity. [provided by RefSeq, Jul 2008]
Description
This gene encodes a phosphoprotein that binds to the Na+/H+ exchanger NHE1. This protein serves as an essential cofactor which supports the physiological activity of NHE family members and may play a role in the mitogenic regulation of NHE1. The protein shares similarity with calcineurin B and calmodulin and it is also known to be an endogenous inhibitor of calcineurin activity. [provided by RefSeq, Jul 2008],
Product Name Alternative
CHP1; CHP; Calcineurin B homologous protein 1; Calcineurin B-like protein; Calcium-binding protein CHP; Calcium-binding protein p22; EF-hand calcium-binding domain-containing protein p22
UniProt
Q99653
Swiss Prot
Q99653
Reactivity
Human; Mouse; Rat
Immunogen
Synthesized peptide derived from the Internal region of human CHP.
Target
CHP
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
24kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
24kD
Fragment
IgG
Subcellular Location
Nucleus . Cytoplasm . Cytoplasm, cytoskeleton . Endomembrane system . Endoplasmic reticulum-Golgi intermediate compartment . Endoplasmic reticulum . Cell membrane . Membrane ; Lipid-anchor . Localizes in cytoplasmic compartments in dividing cells. Localizes in the nucleus in quiescent cells. Exported from the nucleus to the cytoplasm through a nuclear export signal (NES) and CRM1-dependent pathway. May shuttle between nucleus and cytoplasm. Localizes with the microtubule-organizing center (MTOC) and extends toward the periphery along microtubules. Associates with membranes of the early secretory pathway in a GAPDH-independent, N-myristoylation- and calcium-dependent manner. Colocalizes with the mitotic spindle microtubules. Colocalizes with GAPDH along microtubules. Colocalizes with SLC9A1
Other Product Names
CHP1; CHP; Calcineurin B homologous protein 1; Calcineurin B-like protein; Calcium-binding protein CHP; Calcium-binding protein p22; EF-hand calcium-binding domain-containing protein p22
Gene ID (Human)
11261

UniProtKB · Q99653

Calcineurin B homologous protein 1

CHP1_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q99653
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CHP1
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
—
Secondary accessions
B2R6H9, Q6FHZ9
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Ligand

CalciumMetal-binding

Cellular component

Cell membraneCytoplasmCytoskeletonEndoplasmic reticulumMembraneNucleus

Disease

Disease variantNeurodegeneration

PTM

LipoproteinMyristatePhosphoprotein

Molecular function

Protein kinase inhibitor

Biological process

Protein transportTransport

Domain

Repeat

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