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C/EBP α rabbit pAb

CAT: 0855-ES4489-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES4489-02Size:100 µL
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Background
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013]
Description
This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain and recognizes the CCAAT motif in the promoters of target genes. The encoded protein functions in homodimers and also heterodimers with CCAAT/enhancer-binding proteins beta and gamma. Activity of this protein can modulate the expression of genes involved in cell cycle regulation as well as in body weight homeostasis. Mutation of this gene is associated with acute myeloid leukemia. The use of alternative in-frame non-AUG (GUG) and AUG start codons results in protein isoforms with different lengths. Differential translation initiation is mediated by an out-of-frame, upstream open reading frame which is located between the GUG and the first AUG start codons. [provided by RefSeq, Dec 2013],
UniProt
P49715
Swiss Prot
P49715
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human C/EBP-alpha. AA range:6-55
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.
Molecular Weight
42kd
Storage Conditions
-20°C/1 year
Observed Molecular Weight
42kd
Fragment
IgG
Subcellular Location
Nucleus .; [Isoform 4]: Nucleus, nucleolus .
Other Product Names
CEBPA; CCAAT/enhancer-binding protein alpha; C/EBP alpha
Gene ID (Human)
1050

UniProtKB · P49715

CCAAT/enhancer-binding protein alpha

CEBPA_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P49715
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CEBPA
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
C/EBP alpha
EC number
—
Processing
—
Secondary accessions
A7LNP2, P78319, Q05CA4
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

PTM

AcetylationIsopeptide bondPhosphoproteinUbl conjugation

Molecular function

ActivatorDevelopmental proteinDNA-binding

Coding sequence diversity

Alternative initiation

Disease

Disease variant

Biological process

Host-virus interactionTranscriptionTranscription regulation

Cellular component

Nucleus

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