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CDKN3 rabbit pAb

CAT: 0855-ES4465-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES4465-02Size:100 µL
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Background
The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Description
The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008],
UniProt
Q16667
Swiss Prot
Q16667
Reactivity
Human; Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human CDKN3. AA range:31-80
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
23kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
23kD
Fragment
IgG
Subcellular Location
Cytoplasm, perinuclear region .
Other Product Names
CDKN3; CDI1; CIP2; KAP; Cyclin-dependent kinase inhibitor 3; CDK2-associated dual-specificity phosphatase; Cyclin-dependent kinase interactor 1; Cyclin-dependent kinase-interacting protein 2; Kinase-associated phosphatase
Gene ID (Human)
1033

UniProtKB · Q16667

Cyclin-dependent kinase inhibitor 3

CDKN3_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
Q16667
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
CDKN3
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
3.1.3.16, 3.1.3.48
Processing
—
Secondary accessions
Q53ZU6, Q5U0M4, Q6P1N8, Q99585, Q9BPW7, Q9BY36, Q9C042, Q9C046, Q9C047, Q9C049, Q9C051, Q9C053
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Biological process

Cell cycle

Cellular component

Cytoplasm

Disease

Disease variant

Molecular function

HydrolaseProtein phosphatase

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