ADAR1 rabbit pAb

CAT: 0855-ES4459-01Size: 50 µLDry Ice: NoHazardous: No
CAT#:0855-ES4459-01Size:50 µL
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Background
Adenosine deaminase, RNA specific (ADAR) Homo sapiens This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]
Description
Adenosine deaminase, RNA specific (ADAR) Homo sapiens This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010],
UniProt
P55265
Swiss Prot
P55265
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from human ADAR1. AA range:1172-1221
Clonality
Polyclonal
Source
Rabbit
Applications
IHC; IF; WB; ELISA
Concentration
1 mg/ml
Dilution
WB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.
Molecular Weight
135kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
135kD
Fragment
IgG
Subcellular Location
[Isoform 1]: Cytoplasm . Nucleus . Shuttles between the cytoplasm and nucleus (PubMed:7565688, PubMed:24753571) . Nuclear import is mediated by TNPO1 (PubMed:24753571) . .; [Isoform 5]: Cytoplasm . Nucleus . Nucleus, nucleolus . Predominantly nuclear but can shuttle between nucleus and cytoplasm. TNPO1 can mediate its nuclear import whereas XPO5 can mediate its nuclear export. .
Other Product Names
ADAR; ADAR1; DSRAD; G1P1; IFI4; Double-stranded RNA-specific adenosine deaminase; DRADA; 136 kDa double-stranded RNA-binding protein; p136; Interferon-inducible protein 4; IFI-4; K88DSRBP
Gene ID (Human)
103

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