ADAR1 rabbit pAb

• Background:

  Adenosine deaminase, RNA specific (ADAR) Homo sapiens This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]

• Description:

  Adenosine deaminase, RNA specific (ADAR) Homo sapiens This gene encodes the enzyme responsible for RNA editing by site-specific deamination of adenosines. This enzyme destabilizes double-stranded RNA through conversion of adenosine to inosine. Mutations in this gene have been associated with dyschromatosis symmetrica hereditaria. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010],

• UniProt:

  P55265

• Swiss Prot:

  P55265

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human ADAR1. AA range:1172-1221

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  IHC; IF; WB; ELISA

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:500-2000 Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

• Molecular Weight:

  135kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  135kD

• Fragment:

  IgG

• Subcellular Location:

  [Isoform 1]: Cytoplasm . Nucleus . Shuttles between the cytoplasm and nucleus (PubMed:7565688, PubMed:24753571) . Nuclear import is mediated by TNPO1 (PubMed:24753571) . .; [Isoform 5]: Cytoplasm . Nucleus . Nucleus, nucleolus . Predominantly nuclear but can shuttle between nucleus and cytoplasm. TNPO1 can mediate its nuclear import whereas XPO5 can mediate its nuclear export. .

• Other Product Names:

  ADAR; ADAR1; DSRAD; G1P1; IFI4; Double-stranded RNA-specific adenosine deaminase; DRADA; 136 kDa double-stranded RNA-binding protein; p136; Interferon-inducible protein 4; IFI-4; K88DSRBP

• Gene ID (Human):

  103