WAVE2 rabbit pAb

• Background:

  This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID:10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]

• Description:

  This gene encodes a member of the Wiskott-Aldrich syndrome protein family. The gene product is a protein that forms a multiprotein complex that links receptor kinases and actin. Binding to actin occurs through a C-terminal verprolin homology domain in all family members. The multiprotein complex serves to tranduce signals that involve changes in cell shape, motility or function. The published map location (PMID: 10381382) has been changed based on recent genomic sequence comparisons, which indicate that the expressed gene is located on chromosome 1, and a pseudogene may be located on chromosome X. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011],

• Synonyms:

  WASF2; WAVE2; Wiskott-Aldrich syndrome protein family member 2; WASP family protein member 2; Protein WAVE-2; Verprolin homology domain-containing protein 2

• Gene ID:

  10163

• UniProt:

  Q9Y6W5

• Cellular Locus:

  Cytoplasm, cytoskeleton. Cell projection, lamellipodium. Basolateral cell membrane. At the interface between the lamellipodial actin meshwork and the membrane..

• Host:

  Rabbit

• Species Reactivity:

  Human, Mouse, Rat

• Reactivity:

  Human; Mouse; Rat

• Immunogen:

  The antiserum was produced against synthesized peptide derived from human WASF2. AA range:141-190

• Clonality:

  Polyclonal

• Isotype:

  IgG

• Source:

  Rabbit

• Applications:

  WB; IHC; IF; ELISA

• Validated Applications:

  WB, IHC, IF, ELISA

• Stability:

  -20°C / 1 year

• Concentration:

  1 mg/mL

• Dilution:

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

• Molecular Weight:

  55kD

• Storage Conditions:

  PBS with 0.02% sodium azide and 50% glycerol pH 7.4. Store at -20°C. Avoid repeated freeze-thaw cycles.

• Observed Molecular Weight:

  55kD

• Subcellular Location:

  Cytoplasm, cytoskeleton . Cell projection, lamellipodium . Basolateral cell membrane . At the interface between the lamellipodial actin meshwork and the membrane. .

• Other Product Names:

  WASF2; WAVE2; Wiskott-Aldrich syndrome protein family member 2; WASP family protein member 2; Protein WAVE-2; Verprolin homology domain-containing protein 2

• Gene ID (Human):

  10163

• SwissProt (Human):

  Q9Y6W5