LIFR rabbit pAb

• Background:

  Leukemia inhibitory factor receptor alpha (LIFR) Homo sapiens This gene encodes a protein that belongs to the type I cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t (5;8) (p13; q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

• Description:

  Leukemia inhibitory factor receptor alpha (LIFR) Homo sapiens This gene encodes a protein that belongs to the type I Cytokine receptor family. This protein combines with a high-affinity converter subunit, gp130, to form a receptor complex that mediates the action of the leukemia inhibitory factor, a polyfunctional Cytokine that is involved in cellular differentiation, proliferation and survival in the adult and the embryo. Mutations in this gene cause Schwartz-Jampel syndrome type 2, a disease belonging to the group of the bent-bone dysplasias. A translocation that involves the promoter of this gene, t (5;8) (p13;q12) with the pleiomorphic adenoma gene 1, is associated with salivary gland pleiomorphic adenoma, a common type of benign epithelial tumor of the salivary gland. Multiple splice variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008],

• UniProt:

  P42702

• Swiss Prot:

  P42702

• Reactivity:

  Human; Rat; Mouse

• Immunogen:

  The antiserum was produced against synthesized peptide derived from the Internal region of human LIFR. AA range:731-780

• Clonality:

  Polyclonal

• Source:

  Rabbit

• Applications:

  WB; ELISA; IHC

• Concentration:

  1 mg/ml

• Dilution:

  WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

• Molecular Weight:

  120kD

• Storage Conditions:

  -20°C/1 year

• Observed Molecular Weight:

  120kD

• Fragment:

  IgG

• Subcellular Location:

  [Isoform 1]: Cell membrane; Single-pass type I membrane protein.; [Isoform 2]: Secreted.

• Other Product Names:

  LIFR; Leukemia inhibitory factor receptor; LIF receptor; LIF-R; CD118

• Gene ID (Human):

  3977