Products for Research Use Only
RegisterLogin

Integrin α6 rabbit pAb

CAT: 0855-ES4320-01Size: 50 µLDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0855-ES4320-01Size:50 µL
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Background
Integrin subunit alpha 6 (ITGA6) Homo sapiens The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Description
Integrin subunit alpha 6 (ITGA6) Homo sapiens The gene encodes a member of the integrin alpha chain family of proteins. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 6 subunit. This subunit may associate with a beta 1 or beta 4 subunit to form an integrin that interacts with extracellular matrix proteins including members of the laminin family. The alpha 6 beta 4 integrin may promote tumorigenesis, while the alpha 6 beta 1 integrin may negatively regulate erbB2/HER2 signaling. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015],
Product Name Alternative
ITGA6; Integrin alpha-6; CD49 antigen-like family member F; VLA-6; CD49f
UniProt
P23229
Swiss Prot
P23229
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human ITGA6. AA range:901-950
Target
Integrin α6
Clonality
Polyclonal
Source
Rabbit
Applications
WB; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
125kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
125kD
Fragment
IgG
Subcellular Location
Cell membrane ; Single-pass type I membrane protein . Cell membrane ; Lipid-anchor .
Other Product Names
ITGA6; Integrin alpha-6; CD49 antigen-like family member F; VLA-6; CD49f
Gene ID (Human)
3655

UniProtKB · P23229

Integrin alpha-6

ITA6_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P23229
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ITGA6
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
B2RMU9, B4DG69, B4DKB8, C4AM96, G5E9H1, Q08443, Q0MRC7, Q14646, Q16508, Q53RX7, Q59HB7, Q86VL6, Q9UCT1, Q9UN03
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

CalciumMetal-binding

Biological process

Cell adhesion

Cellular component

Cell membraneMembrane

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoproteinLipoproteinPalmitatePhosphoprotein

Disease

Epidermolysis bullosa

Molecular function

IntegrinReceptor

Domain

RepeatSignalTransmembraneTransmembrane helix

Related Products

CatalogName
ES1063-01Cleaved-Integrin α6 LC (E942) rabbit pAb
ES2629-01Integrin αV rabbit pAb
ES2628-01Integrin α3 rabbit pAb
ES4319-01Integrin α5 rabbit pAb
ES8646-01Integrin α1 rabbit pAb
ES5949-01Integrin β1 rabbit pAb
ES4308-01Integrin αL rabbit pAb
ES4190-01Integrin αD rabbit pAb
ES4191-01Integrin β2 rabbit pAb
ES5952-01Integrin β2 rabbit pAb

Alternative Products

CatalogName
E2251687Integrin αD/Integrin alpha 4 Rabbit pAb
MBS8540581-01Integrin alphaX Rabbit pAb
MBS8540550-01Integrin alpha3 Rabbit pAb
MBS8540480-01Integrin beta2 Rabbit pAb
MBS8540377-01Integrin alphaE Rabbit pAb
MBS8540319-01Integrin alpha2 Rabbit pAb
MBS8541861-01Integrin beta3 Rabbit pAb
MBS028968Rabbit Integrin ELISA Kit
E2252330Integrin αL Rabbit pAb
E2251711Integrin α2 Rabbit pAb

Popular Products