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Integrin α5 rabbit pAb

CAT: 0855-ES4319-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES4319-02Size:100 µL
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Background
Integrin subunit alpha 5 (ITGA5) Homo sapiens The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015]
Description
Integrin subunit alpha 5 (ITGA5) Homo sapiens The product of this gene belongs to the integrin alpha chain family. Integrins are heterodimeric integral membrane proteins composed of an alpha subunit and a beta subunit that function in cell surface adhesion and signaling. The encoded preproprotein is proteolytically processed to generate light and heavy chains that comprise the alpha 5 subunit. This subunit associates with the beta 1 subunit to form a fibronectin receptor. This integrin may promote tumor invasion, and higher expression of this gene may be correlated with shorter survival time in lung cancer patients. Note that the integrin alpha 5 and integrin alpha V subunits are encoded by distinct genes. [provided by RefSeq, Oct 2015],
Product Name Alternative
ITGA5; FNRA; Integrin alpha-5; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD49e
UniProt
P08648
Swiss Prot
P08648
Reactivity
Human; Mouse; Rat
Immunogen
The antiserum was produced against synthesized peptide derived from the Internal region of human ITGA5. AA range:561-610
Target
Integrin α5
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. IHC-p: 1:100-1:300. ELISA: 1/10000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
115kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
115kD
Fragment
IgG
Subcellular Location
Membrane; Single-pass type I membrane protein. Cell junction, focal adhesion . Cell surface .
Other Product Names
ITGA5; FNRA; Integrin alpha-5; CD49 antigen-like family member E; Fibronectin receptor subunit alpha; Integrin alpha-F; VLA-5; CD49e
Gene ID (Human)
3678

UniProtKB · P08648

Integrin alpha-5

ITA5_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P08648
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ITGA5
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
—
EC number
—
Processing
Precursor
Secondary accessions
Q96HA5
Protein keywords

Technical term

3D-structureDirect protein sequencingProteomics identificationReference proteome

Ligand

CalciumMetal-binding

Biological process

Cell adhesionHost-virus interaction

Cellular component

Cell junctionCell membraneMembrane

PTM

Cleavage on pair of basic residuesDisulfide bondGlycoproteinPhosphoprotein

Molecular function

Host cell receptor for virus entryIntegrinReceptor

Domain

RepeatSignalTransmembraneTransmembrane helix

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