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SERCA2 rabbit pAb

CAT: 0855-ES4181-02Size: 100 µLDry Ice: NoHazardous: No
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CAT#:0855-ES4181-02Size:100 µL
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Background
This gene encodes one of the SERCA Ca (2+) -ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2008]
Description
This gene encodes one of the SERCA Ca (2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol into the sarcoplasmic reticulum lumen, and is involved in regulation of the contraction/relaxation cycle. Mutations in this gene cause Darier-White disease, also known as keratosis follicularis, an autosomal dominant skin disorder characterized by loss of adhesion between epidermal cells and abnormal keratinization. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2008],
Product Name Alternative
ATP2A2; ATP2B; Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; SERCA2; SR Ca (2+) -ATPase 2; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca (2+) ATPase
UniProt
P16615
Swiss Prot
P16615
Reactivity
Human; Mouse; Rat; Chicken
Immunogen
The antiserum was produced against synthesized peptide derived from the C-terminal region of human ATP2A2. AA range:841-890
Target
SERCA2
Clonality
Polyclonal
Source
Rabbit
Applications
WB; IHC; IF; ELISA
Concentration
1 mg/ml
Dilution
Western Blot: 1/500 - 1/2000. IHC-p: 1/100-1/300. ELISA: 1/20000. Not yet tested in other applications.
Buffer
-20°C/1 year
Molecular Weight
115kD
Storage Conditions
-20°C/1 year
Observed Molecular Weight
115kD
Fragment
IgG
Subcellular Location
Endoplasmic reticulum membrane ; Multi-pass membrane protein . Sarcoplasmic reticulum membrane ; Multi-pass membrane protein .
Other Product Names
ATP2A2; ATP2B; Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; SERCA2; SR Ca (2+) -ATPase 2; Calcium pump 2; Calcium-transporting ATPase sarcoplasmic reticulum type, slow twitch skeletal muscle isoform; Endoplasmic reticulum class 1/2 Ca (2+) ATPase
Gene ID (Human)
488

UniProtKB · P16615

Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

AT2A2_HUMAN · Homo sapiens

View on UniProt ↗
Primary accession
P16615
Review status
UniProtKB reviewed (Swiss-Prot)
Gene
ATP2A2
Protein existence
1: Evidence at protein level
Organism
Homo sapiens (Human)
Taxonomy ID
9606
Alternative names
SERCA2, SR Ca(2+)-ATPase 2
EC number
7.2.2.10
Processing
—
Secondary accessions
A6NDN7, B4DF05, P16614, Q86VJ2
Protein keywords

Technical term

3D-structureProteomics identificationReference proteome

Coding sequence diversity

Alternative splicing

Ligand

ATP-bindingCalciumMagnesiumMetal-bindingNucleotide-binding

Biological process

Calcium transportIon transportTransport

Disease

Disease variantEpilepsy

PTM

Disulfide bondNitrationPhosphoprotein

Cellular component

Endoplasmic reticulumMembraneSarcoplasmic reticulum

Molecular function

Translocase

Domain

TransmembraneTransmembrane helix

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